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Agents in this group include peroxisome proliferator-activated receptor agonists (e.g., pioglitazone, elafibranor, saroglitazar), bile acid-farnesoid X receptor axis regulators (obeticholic acid), de novo lipogenesis inhibitors (aramchol, NDI-010976), and fibroblast growth factor 21/19 analogs

Tirzepatide does not have established therapeutic concentration thresholds, and clinical decisions should be based on FDA labeling and clinical judgment rather than estimated drug levels

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Glucagon-like peptide-1 receptor: Mechanisms and advances in therapy