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The basic reason GLP-1R agonism works for weight loss is that GLP-1 regulates appetite

The key is consistency and context

A personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 is a contraindication for all GLP-1 receptor agonists

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If you are deciding between the two, the choice typically comes down to whether the GIP component of tirzepatide is worth the potentially higher cost and different side effect profile