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We summarised the current evidence and available recommendations from the ASA and ESAIC to support clinicians in the perioperative management of patients receiving SGLT2 inhibitors, GLP-1RAs and related therapies (Table 2)

Decreasing the liberation of glutamate from the glutathione cycle leads to decreased cortical neuron glutamate, while decreasing the utilization of glutamate increases total glutamate by about 25%

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This reclassification has significantly impacted access through legitimate medical channels

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