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[63] Pernicious anemia can be treated with intramuscular injections of vitamin B 12

A attracts and activates microglia and astrocytes, leading to the release of pro-inflammatory mediators such as TNF, IL-6, IL-2, and IL-1, as well as reactive oxygen and nitrogen species produced by oxidative stress, which ultimately leads to neuronal cell death (35)

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Nature 438 , 662666 (2005)