Key Takeaways Tirzepatide (Zepbound) produces greater average weight loss than semaglutide (Wegovy) across both clinical trials and the first direct head-to-head comparison, 20.9% versus 14.9% in separate Phase 3 trials, and 20.2% versus 13.7% in the SURMOUNT-5 trial published in the New England Journal of Medicine
What are the potential side effects of tirzepatide, and how common are they
It can cause rapid weight loss and associated facial side effects that some call Ozempic face. You should only use Ozempic as your doctor recommends
Continue taking any additives or supplements your provider has recommended
As a result, many women experience: Acne or breakouts Melasma (dark patches on the face) Dry, itchy, or sensitive skin Stretch marks Darkening of nipples, underarms, and inner thighs These changes are normal and usually temporary, but proper care can help manage them safely