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Just 50 a day (not 250, or 2,000 once a week, not 2,500) reliably bought blood levels up, and more importantly, normalized methylmalonic acid and homocysteine levels within a matter of months

Underdosing is the most common reason for suboptimal outcomes

For example, a co-crystallization strategy reveals that ML162 effectively targets all catalytic tetrad residues in GPX4 by interacting with Sec46, Gln81, Trp136, and Asn137, thereby completely obstructing the active site [218]

This area of research is nascent and requires significant further validation

Trials have typically used titration periods of about 6 weeks, starting at a lower dose and stepping up to the full maintenance dose