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Hepatocellular hypertrophy is considered a hallmark of enzyme induction when there is an increased protein synthesis or increased number of cytoplasmic organelles

It has a dual mechanism

Urgent medical attention is required for severe or persistent abdominal pain (especially if radiating to the back), persistent vomiting preventing adequate fluid intake, signs of dehydration, blood in vomit, black stools, or jaundice, as these may indicate serious conditions such as pancreatitis or gallbladder disease

Ocul Surf 24:2230 Ghannoum MA, Rice LB (1999) Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance