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Free radicals can damage renal tubular cells and disrupt the function of sodium transporters, leading to sodium retention and increased blood volume, which further elevates blood pressure [82]

Women of childbearing potential must use effective contraception during treatment and add non-hormonal backup contraception for 4 weeks when initiating or increasing tirzepatide doses due to potential decreased oral contraceptive effectiveness

The decision to continue, adjust, or discontinue treatment should always be made collaboratively, weighing the benefits of glycaemic control or weight management against any side effects experienced