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Ca 2+ also activates the cysteine protease calpain-1, which degrades cytoskeletal proteins such as the ankyrin-R complex, promoting membrane blebbing and increasing cellular adhesiveness (Restivo et al., 2021)

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this can then limit the expected recovery of Haemoglobin

Most patients experience no discomfort

This may be averted through co-treatment with IFN-, which has been shown to expand the Arg1+ microglial subset and reduce infarct volume and BBB disruption (Kuo et al., 2023)