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Safety and Tolerability Key Findings: AOD-9604 has been shown to be safe and well-tolerated in clinical trials, with no reported impact on IGF-1 levels or growth hormone pathways

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Other researchers have shown that nursing home residents frequently have burdensome transitions at the end of life, including admission to an intensive care unit in the last month of life and late enrollment in hospice, 958 although the number of care transitions for nursing home residents with advanced cognitive impairment varies substantially across geographic regions of the United States

The selectivity for beta-3 receptors explains the favorable safety profile compared to non-selective beta agonists that cause cardiovascular stimulation and other systemic effects