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More rigorous randomized trials for fibromyalgia, diabetic neuropathy, and other chronic pain syndromes are needed
The SURPASS-3 study was set up to investigate the efficacy and safety of tirzepatide versus a titration of the basal insulin degludec inadequately controlled by an oral therapy of T2D by metformin with or without an SGLT2 inhibitor comedication for 52 weeks (72)
For adults over 40 on GLP-1 medications, the choice between strength and cardio isn't really a choice it's a sequence
Despite best efforts, it is possible that some patients will not comply with fasting recommendations while continuing their GLP-1 RA
The LEADER trial with liraglutide reported a reduction in MACE (HR 0.87), while the REWIND trial with dulaglutide demonstrated an HR of 0.88
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