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Uric acid can enhance MAPK pathway-mediated proliferation in rat primary vascular smooth muscle cells via controlling of mitochondria and caspase-dependent cell death

PMID: 29311918

Several toxic oxides produced by this chain reaction can destroy the fluidity and structural stability of cell membranes, leading to cell rupture and death

How they work: They block glucose reabsorption in the kidneys proximal tubule, so excess glucose is excreted in the urine