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(2) Unlike acetylcholine, bethanechol resists hydrolysis by cholinesterase, resulting in a longer duration of action

TREM2 agonists, such as AL002, promote microglial transformation toward the anti-inflammatory M2 phenotype, thereby reducing the release of pro-inflammatory M1 cytokines (e.g., TNF-, IL-1) and indirectly mitigating inflammation-driven ferroptotic cascades

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