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B.Mrsic-FlogelT

Animal Reproduction Science

As people age, growth hormone production declinesa phenomenon sometimes called "somatopause." Research on GHRH peptides (including sermorelin) has explored effects on body composition, sleep quality, metabolic markers, and physical function in adults with age-related GH decline

Firstly, by dampening inflammatory responses integral to the pathophysiology of depression and anxiety, omega-3 PUFAs and their metabolites can inhibit leukocyte chemotaxis, reduce the expression of adhesion molecules, decrease the production of pro-inflammatory mediators, and encourage a shift in microglia polarization towards a reparative, non-inflammatory state (75, 76)

A small percentage of users report sleep disturbances with evening dosing, possibly related to nitric oxide system effects