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Moreover, the percentage of participants in clinical trials who stopped the treatment due to AE was 515% with most of the new agents, and this percentage was up to 2030% with some of GLP-1/glucagon RA in phase 2 trials so a considerable proportion of people may not be able to tolerate the new obesity pharmacotherapies or may be unable to titrate them to the higher and most effective doses

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Etamicastat, chronically administered in drinking water, also significantly reduced both blood pressure and urinary NE excretion but increased urinary DA excretion in the SHR [4]

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