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Applying a cold compress for 5 minutes before injection numbs the area slightly and can reduce local reactions

Drug Discovery Today, 20(1), 122-128

Focal injuries like specific tendon damage may benefit from local perilesional injection

These include: Hypoglycemia (low blood sugar) Acute pancreatitis (inflammation of the pancreas) Changes in vision (due to diabetic retinopathy) Gallbladder problems Kidney injury Severe stomach problems Allergic or hypersensitivity reaction If you need to have surgery while taking tirzepatide, inform your healthcare provider, as the medication increases the risk of aspiration during anesthesia or deep sedation

A metallic taste can also be an early sign of gum disease, dry mouth or infection