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Lead toxicity can be traced back to Roman times with lead plumbing and Sapa, a concentrated grape juice prepared in lead vessels that resulted in the syrup containing a gram per litre

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The type of oligomerization loop in rhGPx3 mutant is mainly lined by hydrophilic residues (Thr-165, Ser-166, Asp-167, Arg-168, Trp-171 and Glu-172) and the surface of oligomerization loop is negatively charged (Figure 4b)