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Consistently feeling sad, empty, and hopeless Markedly diminished interest in pleasurable activities Significant weight loss or weight gain Increased or decreased appetite Insomnia or hypersomnia Fatigue or loss of energy Feeling of worthlessness, feeling excessive, or inappropriate guilt Diminished ability to think or concentrate, or indecisiveness Recurrent thoughts of death and suicidal ideation without a specific plan Psychomotor agitation or retardation These symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning

Additionally, these are not components of FDA-approved drugs and have not been found safe and effective for any condition. At this time, these drugs are only legally accessible to clinical trial patients

doi: 10.1007/s12265-023-10432-3 53 KosmasCEBousvarouMDKostaraCEPapakonstantinouEJSalamouEGuzmanE

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We next attempted to rescue mitochondrial oxidative phosphorylation and glycolysis by co-supplementation with antioxidants, both cell-wide (2.5 mM GSH and 25 M Trolox) and mitochondrial-targeted [10 nM mitoquinol (MQ) and 1 nM SKQ1] (22, 23)