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The study authors said they believe coming off the drug creates a kind of metabolic whiplash. After stopping, the heart benefits seemed to be reversed more quickly than it took to get them in the first place, said study author Dr

However, given the superior CV benefits of GLP-1RAs, which differ somewhat from those attributed to SGLT2 inhibitors, we cardiologists also need to consider the CV benefits of GLP-1RAs and become more comfortable prescribing the agents for appropriate patients who may benefit the most from them