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Alpha-2 agonists (clonidine, dexmedetomidine) sometimes used clinically to blunt ketamines blood-pressure rise without reducing the antidepressant effect

"For my Zepbound patients, I also recommend avoiding large or high-fat meals, which can worsen nausea, vomiting, and diarrhea." Temporarily following a bland diet or a BRAT diet (bananas, rice, applesauce, toast) may also help treat Zepbound diarrhea

In addition, amyloid- proteins contribute to degeneration of basal forebrain cholinergic neurons

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Wegovy, administered as a once weekly semaglutide injection, has demonstrated significant weight loss benefits, especially when paired with a reduced calorie diet and lifestyle interventions