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Finally, the pleiotropy-original sin hypothesis postulates that cell death is an immanent and inevitable process associated with the formation of metabolic by-products in cells like reactive oxygen species (ROS) and cell death machinery components-encoding genes were not initially related to cell death processes and performed pro-survival functions

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Bars: 50 m ( b ) Correlation of fluorescent signal originating from the sfEGFP signal of the gB or VSV-G constructs and the Alexa647 labelled Nb1_gbHSV of three independent experiments (n = 3) in five positions each

Tomassoni D, Di Cesare Mannelli L, Bramanti V, et al

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