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PSCA-targeted modalities, including radiolabeled antibodies and CAR T cell therapy, have shown encouraging antitumor activity in both the preclinical and clinical settings, indicating the feasibility of PSCA as a target for ADCs 215,216

Neutrophils, mononuclear phagocytes, and lymphocytes accumulate vitamin C to high concentrations, which can protect these cell types from oxidative damage (12-14)