GLP-1related weight loss tends to build over months and may continue for some time before stabilizing after a little more than a year on average
Exemplifying this potential, nipocalimab has been shown to potently reduce the level of pre-existing neutralizing Abs against adeno-associated virus vectors in NHPs with moderate Ab titers, which improved vector transduction efficacy to target tissues to close to that observed in Ab-negative nave control animals [360]
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55,190,194 It is currently elusive why the GLP-1 response occurs so rapidly but it is speculated that L-cells in the upper jejunum and the vagal nerve play a role