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However, further studies are needed to conclusively clarify the mechanisms underlying these protective effects

Zhu Z, Han Z, Halabelian L, Yang X, Ding J, Zhang N, et al

Increased response to oxidative stress challenge in Graves ophthalmopathy orbital fibroblasts

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The polymorphism is caused by a single point mutation (G to A nucleotide substitution), leading to a substitution of lysine for glutamate at position 487 (E487K) in the ALDH2 monomer [5]