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Other GLP-1 Medications: Dulaglutide (Trulicity): Once-weekly GLP-1 agonist FDA-approved for diabetes only Not typically prescribed for weight loss Modest weight loss (3-5 kg average) Exenatide (Byetta, Bydureon): Older GLP-1 agonist Daily or weekly depending on formulation Less effective than newer options Rarely used now Oral Semaglutide (Rybelsus): Daily tablet form of semaglutide Much less effective than injectable (3-5% weight loss) Strict dosing requirements (empty stomach, wait 30 minutes) Not recommended for weight loss Side-by-Side Comparison: Which GLP-1 Should You Choose

The SELECT trial, published in 2024, showed that semaglutide reduced major adverse cardiovascular events (MACE: heart attack, stroke, cardiovascular death) by 20% in individuals with obesity, even independent of weight loss magnitude. Why

Why GLP-1 Users May Experience Skin Laxity One of the most common concerns among GLP-1 program users is the appearance of loose skin, especially in the face and neck

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Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy