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Proteostasis can be treated as a systems-level control problem: cells must continuously maintain a functional proteome despite stochastic translation errors, folding challenges, chemical damage, and fluctuating metabolic demands

Interferon- inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

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Chen et al., 2021