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S.BoehmeM.et al (2019)

Copper peptides are not safe for everyone: those with copper allergy, active rosacea, severe eczema, or a severely damaged barrier should avoid them and consider alternatives like PDRN or niacinamide

However, the cell death, proteasome inhibition and apoptosis were observed using 1 mM ibuprofen, which is significantly higher than the peak ibuprofen concentrations found in human blood (58.4 g/mL or 283.09 M) after high doses of ibuprofen 39 , and as such may not be physiologically relevant

Table 1 Key trials reporting prediabetes remission and dietary features

Finally, safety and selectivity considerations will shape the translational path