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Tesamorelin has the strongest evidence for reducing visceral abdominal fat in adults with HIV-associated lipodystrophy, while GLP-1/GIP medications such as semaglutide and tirzepatide are generally stronger options for overall weight loss

Food and Drug Administration (FDA) has given it "Generally Recognized as Safe" (GRAS) status for use in food products

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While this acute effect has been studied primarily in the context of cardioprotection research, any acute hemodynamic modulation carries theoretical safety implications in research models involving compromised cardiovascular function