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Of these patients, 4 underwent a vitamin C on-off study which demonstrated a positive dose response relationship with neurological symptoms . A separate prospective trial into a diverse number of therapies indicated that vitamin C improved motor disability grades in HAM/TSP in 20% of patients (93)

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This implies that upstream modulators like KEAP1 may be more important than direct Nrf2 modulation as the primary mechanism 104

P., Bhargava, R., Dahan, S., Tsokos, M