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The current evidence does not support a direct mechanism by which semaglutide would cause joint inflammation or damage

My shoulders had been through serious work and come out the other side stronger for it

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doi:10.1016/S0021-9258(18)53812-6

(2015) discovered that exendin-4 treatment in Glp1r+/+ mice elevated cAMP levels in isolated intraepithelial lymphocytes while reducing the transcription of multiple inflammatory mediators, including IL-1, IL-6, IL-22, IL-12, TNF-, CCL2, CXCL1, and CXCL2