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The goal should not simply be weight loss, he says

This is when most people want to quit

Behavioral intervention involved counseling by a dietitian or equivalent healthcare professional every 4 weeks through in-person visits or telephone sessions, focusing on adhering to a reduced-calorie diet (500 kcal deficit per day compared to estimated energy expenditure at randomization) and increased physical activity (encouraging 150 minutes per week, such as walking), with daily recording (via diary, app, or other tools) reviewed during counseling sessions

Notably, GLS-mediated deamination of glutamine to glutamate is the first and rate-limiting step of glutaminolysis, making it an attractive druggable target 9

Appel L, Bergstrom M, Buus Lassen J, Langstrom B Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET