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The enzyme, thus, contributed two pivotal aspects that characterize reactions in living organisms: adequate reaction velocity and appropriate specificity

Fluctuating serotonin levels have recently been implicated in the after-effects of STN DBS due to data reporting that (1) cognitive and depressive symptoms develop after stimulation and (2) anti-Parkinsonian drugs reduce serotonin in the prefrontal cortex and hippocampus, and (3) selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine enhance responsiveness to neurostimulation [371,373,373]

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10.1002/cpt.125 57