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Ferroptotic cells exhibit characteristic features including outer mitochondrial membrane rupture, unusually small mitochondria, and less pronounced or even absent cristae ( Yes-associated protein (YAP) is a downstream transcriptional activator in the Hippo pathway that controls the survival and proliferation of cardiomyocytes and many other cells, regulating a diverse array of oxidative stress- and apoptosis-related pathological and physiological activities ( Pyrroloquinoline quinone (PQQ) is a natural water-soluble redox coenzyme that is found throughout plant and animal tissues, serving as an essential nutrient in mammals with purported cardioprotective activity ( In light of the above evidence, the present study was developed with the hypothesis that PQQ may act as a cardioprotective agent to prevent heart failure via modulating YAP-related anti-ferroptotic activity, thus reducing the severity of myocardial hypertrophy