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Cost savings come from eliminating manufacturer branding, marketing, and distribution premiumsnot from lower quality standards

Still, "dietary protein should be a priority to help preserve muscle mass" in people taking GLP-1 medications, experts urged in a 2025 advisory published in The American Journal of Clinical Nutrition

They found that participants who took collagen experienced a greater increase in patellar tendon cross-sectional area (+6.8 mm) than the placebo group (+1.2 mm)

In a recent systematic review of 14 RCTs [254], HL-focused interventions led to significant improvements in T2DM health knowledge, quality of life, physical activity levels, and health-related self-efficacy, although inconsistent results were seen across self-management strategies such as glycemic control, foot care, diet management, and medication adherence [254]

Some users of the drug have reported worrying health problems