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On the other hand, chronic alcohol abuse in combination with malnutrition (low hepatic GSH levels), longer duration of supratherapeutic APAP consumption, and older age with potential co-morbidities can trigger hepatotoxicity [179]

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Antibodies and reagents The following antibodies were used in this study: anti-4-hydroxynonenal (4-HNE), Abcam (ab46545), for immunoblotting and IHC

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