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In addition to the mitochondrial pathway, the external activation pathway of apoptosis is mediated by death receptors, specifically manifested as death receptors such as Fas (factor-related apoptosis) and tumor necrosis factor receptor 1 (TNFR1) bind to their ligands (FasL and tumor necrosis factor- (TNF-), respectively), recruiting Caspase-8 via the adaptor protein Fas-associating protein with a novel death domain (FADD) to form the death-inducing signaling complex (DISC)

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