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After reviewing her food diary and adjusting her injection timing, we decided to titrate down slightly and then increase more gradually

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The supplementary biochemical analysis was applied to the DBA/1J mice ( n = 12

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a , Scheme of the in vitro sgRNA competition assay performed in HEK-293T SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA transduced with a pool of 5 control sgRNAs (sgControl, gray) and sgRNAs targeting TXNRD2 (pink) and SLC25A40 (green) (left)