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In addition, BSO decreased the intensity of Ki67 staining and increased that of 4-HNE staining in tumors with high ACTL6A expression, but this trend was not observed in PDX tumors with low ACTL6A expression (Supplementary Fig 8b)

For tirzepatide, hydrolysis at critical positions can completely inactivate the molecule by disrupting the binding interface that interacts with GIP and GLP-1 receptors

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As antiparkinsonian medications, dopamine agonists have been reported to induce GSH biosynthesis in the brain 17,18,19 , indicating that dopamine receptors modulate GSH synthesis

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