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(54) Taken together, these studies suggest that protein intake may need to be reduced along with calories to lower IGF-1 levels

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Effective delivery of IGF-1 to injured cartilage is a prerequisite for growth factors to exert biological functions in vivo

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- -18C - 5

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These alterations compromise epithelial barrier integrity, elevate intestinal permeability, and promote the development of leaky gut syndrome, which in turn triggers inflammatory responses in both the gut and skin [106, 107]

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