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Formulations that maintain acidic pH can both improve peptide stability and support the skin natural acid mantle
This work was supported by grants from the National Key Research and Development Program (2022YFC2304500), the National Natural Science Foundation of China (82270631), the ECCM Program of the Clinical Research Center of Shandong University (2021SDUCRCB006), and the Young Taishan Scholars (tsqn202103169)
GLP-1 RA exenatide alleviated the polycystic ovarian morphology in rats with PCOS, semaglutide treatment not only alleviated PCOS phenotypes but also reversed ovarian ferroptosis markers, restored GPX4 expression, and reduced the GPX4 promoter hypermethylation and DNMTs levels, with efficacy comparable to 5-azacytidine
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