doi: 10.1016/j.clim.2020.108470 33 GuHZhangYZengW
The above studies have underscored ferroptosis as a pivotal mechanism in ALI and positioned MSC-Exos as a multifaceted intervention, targeting SLC7A11, lipid peroxidation, and mitochondrial integrity
Briefly, when muscle is injured, overused, or mechanically stretched, satellite cells are activated to enter the cell cycle through a cascade of events including nitric oxide (NO) radical-dependent release of the active form of HGF (a hetero-dimer of - and -chains) from its extracellular tethering and the subsequent presentation of HGF to the cell-membrane signaling receptor c-met, followed by the sequence of steps including proliferation to produce myoblast progeny, differentiation, and fusion with existing muscle fibers and/or to form new fibers 18,19,20,21,22, 31
Common findings include: Muscle rigidity , including masseter muscle spasm and generalized rigidity (Ndikontar et al., 2020
Quantification of total NADPH levels Total NADPH assay kits (Abcam, #ab186031) were used