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In a mouse model of hepatic encephalopathy, reduced expression of neuronal fractalkine, a molecule that promotes off signaling to microglia, resulted in elevated microglia activation, with increased expression of CCL2, IL-6, and TNF- (McMillin et al., 2016), which was also seen in a hepatic injury modeled by a bile duct ligation (Dhanda et al., 2018)

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Morton JI, Ilomki J, Wood SJ, Bell JS, Shaw JE, Magliano DJ (2022) One-year readmission and mortality following ischaemic stroke by diabetes status, sex, and socioeconomic disadvantage: an analysis of 27,802 strokes from 2012 to 2017